Efficient and Selective Chemical Labeling of Electrochemically Generated Peptides Based on Spirolactone Chemistry
نویسندگان
چکیده
منابع مشابه
Efficient and Selective Chemical Labeling of Electrochemically Generated Peptides Based on Spirolactone Chemistry.
Specific digestion of proteins is an essential step for mass spectrometry-based proteomics, and the chemical labeling of the resulting peptides is often used for peptide enrichment or the introduction of desirable tags. Cleavage of the peptide bond following electrochemical oxidation of Tyr or Trp results in a spirolactone moiety at the newly formed C-terminus offering a handle for chemical lab...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2016
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.6b01154